Cognitive Decline Expert: The Disease That Starts in Your 30s but Kills You in Your 70s

Episode Moments

Cognitive Decline Expert: The Disease That Starts in Your 30s but Kills You in Your 70s

doac
February 5, 2026
24 Moments

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The Single Best Exercise to Protect Your Brain

When asked for the one exercise to do for life to protect the brain, Louisa Nicola chooses the deadlift due to its comprehensive muscle recruitment and neural drive.

fitness advice
22:55
Duration: 0:31

Redefining Success: Controlling Your Brain States

Louisa Nicola defines high performance not as constant output, but as the ability to switch between intense focus and recovery.

performance advice
1:55:21
Duration: 0:55

One Night of Poor Sleep Increases Brain Plaque by 4%

Louisa explains the compounding danger of sleep deprivation and how a single night of poor sleep can immediately increase the hallmarks of Alzheimer's pathology in the brain.

sleep deprivation knowledge
7:05
Duration: 0:23

When Science Meets Faith: Why Biology Points to God

Nicola discusses how the complexity of human development and neurosurgical miracles make it difficult for scientists to ignore the possibility of a higher power.

philosophy knowledge
2:01:50
Duration: 2:17

Why Everyone Should Be Taking Creatine for Their Brain

Louisa Nicola explains how creatine isn't just for muscles; it's a powerful tool for cognitive function, protecting the brain against stress, concussions, and even sleep deprivation.

brain health knowledge
0:05
Duration: 0:19

The Age 65 Deadline for Heart Remodeling

Louisa explains the 'biological expiration date' for heart plasticity, emphasizing why midlife is the critical window for intervention.

longevity knowledge
34:44
Duration: 0:32

Leaky Brain: How Hypertension Kills Your Neurons

An explanation of how high blood pressure destroys the tiny capillaries in the brain, leading to a breakdown of the blood-brain barrier.

brain health knowledge
35:54
Duration: 0:59

Why Menopause Triggers a Brain Energy Crisis

Louisa explains the 30% drop in brain glucose metabolism during menopause and why a ketogenic diet may be a necessary alternative fuel source.

women's health knowledge
44:17
Duration: 1:06

The Brain's Nightly Washing Machine

A description of the glymphatic system and how deep sleep is required to wash out toxic proteins like amyloid beta from the brain.

sleep knowledge
55:33
Duration: 1:06

The Brain Needs More Creatine Than Your Muscles

A breakdown of why the standard 5g dose of creatine isn't enough for cognitive benefits and how high-dose creatine is being used for Alzheimer's patients.

health knowledge
1:16:43
Duration: 1:15

Falling Asleep vs. Staying Asleep: Different Solutions

Louisa Nicola breaks down why a racing mind prevents falling asleep and why heat prevents staying asleep, offering specific supplements like GABA and Glycine for each.

sleep advice
1:04:03
Duration: 1:09

Theodore Roosevelt: How Hardship Forged a President's Brain

A powerful historical example of how extreme physical and emotional hardship can rewire the brain, specifically the AMCC, leading to extraordinary life achievements.

resilience story
1:40:36
Duration: 1:01

The Vitamin D Levels That Slash Alzheimer's Risk by 80%

Exploring the critical link between Vitamin D deficiency and dementia, featuring a study on centenarians that highlights a massive risk reduction.

health knowledge
1:14:41
Duration: 0:19

The Era of Brain Rot: How AI and Scrolling Are Weakening Our Minds

Nicola discusses the negative impact of mindless scrolling and reliance on AI tools like ChatGPT on our cognitive abilities and attention spans.

technology controversy
1:43:34
Duration: 1:35

The Heartbreaking Reason 70% of Alzheimer's Patients are Women

A deeply personal story about Louisa's grandmother that fuels her passion for female-focused neurohealth and the systemic issues in medical literature.

women's health story
1:45:29
Duration: 2:37

Reverse Your Heart Age by 20 Years

Louisa Nicola discusses a landmark study showing that four hours of specific exercise per week can remodel a 50-year-old heart to look like a 30-year-old heart.

heart health knowledge
30:59
Duration: 1:11

The Norwegian 4x4: The Gold Standard for VO2 Max

A specific, actionable exercise protocol designed to maximize VO2 max, which is cited as the strongest predictor of all-cause mortality.

fitness advice
33:07
Duration: 0:43

Why Your Omega-3 Must Be Kept in the Fridge

Louisa Nicola reveals a shocking truth about fish oil supplements: 95% of popular brands are rancid, and keeping them at room temperature makes them worse.

health advice
1:10:39
Duration: 1:13

The $25 Tool to Save Your Brain

Louisa recommends daily blood pressure monitoring as a cheap and effective way to prevent the breakdown of brain capillaries.

health monitoring advice
38:07
Duration: 1:05

The 10-Squat Hack to Counteract Sitting All Day

A simple, actionable tip to combat the negative effects of being 'active sedentary' by performing brief intervals of air squats every hour.

sedentary lifestyle advice
24:20
Duration: 0:55

95% of Alzheimer's Cases Are Preventable Lifestyle Choices

A powerful revelation that Alzheimer's is largely a disease of lifestyle rather than genetics, offering hope that most cases can be avoided through early intervention.

Alzheimer's prevention knowledge
4:22
Duration: 0:53

The Willpower Muscle: How Doing Hard Things Changes Your Brain

Louisa Nicola explains the Anterior Midcingulate Cortex (AMCC), often called the 'willpower muscle,' and how it physically grows when we engage in activities we find difficult or resistant.

neurobiology knowledge
1:36:24
Duration: 1:49

How to Creatine Your Way Out of Sleep Deprivation

Louisa Nicola explains a powerful biohack using high-dose creatine to reverse the cognitive decline associated with a bad night's sleep.

sleep advice
1:22:35
Duration: 0:28

One Night of Bad Sleep Increases Alzheimer's Risk

A stark warning about the immediate impact of sleep deprivation on the buildup of Alzheimer's-related proteins.

sleep controversy
1:01:53
Duration: 0:32