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The hosts discuss modern dental procedures like Invisalign palate expanders and the controversial connection between the work of Khan and Erlick on oral health and the "mewing" phenomenon, emphasizing nasal breathing.
Dr. Huberman describes his tent sauna, which uses incandescent lights and is grounded, effectively creating a "mini Faraday case" where his phone loses signal. This allows him to have a completely digital-free space for relaxation and mental clarity.
Chris asks why legacy media attempts to politicize topics like protein consumption and resistance training. Andrew explains that traditional media outlets are struggling financially and use politicization as a tactic to generate clicks and revenue. He highlights how topics like protein and resistance training, which have clear health benefits, become battlegrounds in this fight for attention.
Andrew Huberman describes the predictable arc that health topics follow in public discourse: starting in niche cultures, gaining excitement and widespread attention, facing pushback and criticism, and eventually reaching acceptance if the information is valid. He uses examples like the glymphatic system, dopamine, and creatine to illustrate this cycle, explaining that initial dismissals are often based on limited or flawed studies.
The discussion covers how sleeping with your head tilted back can increase apnea risk, why fixing snoring is important, and introduces solutions like nose strips and mandibular devices for sleep-induced apnea.
Dr. Huberman highlights David Spiegel's intelligence, kindness, and respectful communication style as crucial for gaining acceptance for groundbreaking scientific ideas, especially for those at the "cutting edge" of their field.
Dr. Huberman emphasizes that the hypothalamus, the seat of primal drives, "isn't going anywhere." He suggests that since these drives are inherent, the key is to find "adaptive and functional" ways to engage them, rather than letting them lead to self-destruction, likening primal "hunt" to the original gamble.
Dr. Huberman recounts the historical anecdote of how a lack of understanding of bacteria and hygiene led to high rates of childbirth deaths, with physicians performing autopsies and then delivering babies without washing hands. He highlights how the simple act of handwashing dramatically reduced these fatalities.
The speaker shares "lesser examples" of the Cassandra complex in modern science. He recounts the initial dismissal of the glymphatic system discovery by a female scientist due to a flawed replication attempt by a more powerful group, and how Alfred Russell Wallace's parallel discovery of natural selection was overshadowed by Darwin due to his social standing. This highlights how scientific truth can be suppressed or overlooked due to power dynamics and club mentality.
Andrew Huberman shares a personal anecdote about legendary bodybuilder Mike Mentzer, who sold him his first training program by phone when Huberman was a teenager. He describes Mentzer's intense personality and his core advice: train hard, stay away from anabolics, live life, and read books. Huberman also discusses Mentzer's insights into effective training, such as the importance of muscle-mind connection for reducing set volume.
Dr. Huberman discusses the difficulty for individuals with "extreme" views in one branch of medicine to gain acceptance, contrasting the "mewing guy" (MW) with his colleague David Spiegel, who successfully integrated hypnosis into mainstream medicine with strong data.
Dr. Huberman praises his colleague David Spiegel for effectively framing hypnosis as a "brain plasticity accelerator" through thoughtful, scientifically-backed communication and a broad, non-tribal approach, making it an accepted tool in medicine.
Huberman hypothesizes that in the pursuit of health, people often layer in new interventions that can create additional, confusing health problems, citing his own experience with a prescription drug. This sets the stage for Chris to discuss his 'sickness journey,' detailing initial symptoms like fatigue, brain fog, and low mood, and his eventual Lyme diagnosis, emphasizing he pursued standard treatments before exploring more extreme options.
Dr. Huberman explains that while habit experts like James Clear provide great protocols, understanding the underlying neuroscience (mechanism) gives individuals more flexibility and ability to customize habit-forming strategies for themselves, leading to better long-term results.
Dr. Huberman highlights that despite readily available "top 10" lists for self-improvement (like sleep), most people don't follow them. He attributes this to the way individuals learn information, which strongly influences their ability to apply it.
Dr. Huberman explains that your current thoughts and ability to focus are heavily influenced by sensory inputs received in the hours and days prior. He suggests that highly stimulating breaks between work sessions can make it harder to concentrate.
This moment highlights that humans thrive not just on learning, but on 'learning and doing,' emphasizing the importance of understanding the underlying mechanisms behind protocols and actions. This depth of knowledge allows for greater flexibility and robustness in applying strategies, rather than blindly following instructions.
This clip illustrates the concept of 'principles below principles' with a practical example of cortisol regulation and explains how this deep understanding allows for adaptive problem-solving. It then transitions into a broader definition of true expertise, contrasting it with simply following protocols.
This clip explores two common forms of burnout – morning exhaustion with late-day energy, or chronically elevated cortisol throughout the day. It then introduces a core strategy for intervention: dedicating the first 3-6 hours as 'go time' with stimulating activities, and intentionally doing the opposite in the evening.
Dr. Huberman underscores that reflection on what you're trying to learn or solve, even if you don't immediately remember or are still puzzled, is crucial for the "anti-forgetting process" and is supported by neuroscience.
Huberman discusses the emerging focus on fiber in diet, highlighting that not all fibers are beneficial for everyone; some can cause inflammation. He then presents research showing that low-sugar fermented foods significantly reduce inflammation and support the gut microbiome, offering examples like sauerkraut and kimchi.
This clip reveals a study demonstrating that even very dim light (100 lux) during sleep can lead to abnormally elevated morning glucose levels. It underscores the evolutionary importance of truly dark nights for optimal metabolic health, linking it to cortisol's role in glucose mobilization.
Huberman issues a strong warning against taking large amounts of melatonin, explaining that despite its antioxidant properties and presence in the body, high doses can suppress the hypothalamic-gonadal axis, potentially delaying puberty in adolescents. He challenges the common misconception that more is better for antioxidant benefits, emphasizing its hormonal role.
This clip explains the non-obvious yet critical connection between morning sunlight exposure and improved sleep quality. It highlights how spiking cortisol in the first hour of your day, triggered by bright light, sets your circadian rhythm for better sleep 14 hours later.
For those struggling to fall and stay asleep despite good sleep hygiene, this clip suggests examining carbohydrate intake. It explains that for many, especially those on very low-carb diets, a small amount of starchy carbohydrates in the final meal can significantly improve sleep quality.
This clip challenges the modern perception of 'comfort foods' as junk food. It explains that true comfort foods are traditionally starchy, warm items that biologically suppress cortisol, offering genuine physiological comfort rather than just emotional indulgence.
A humorous and lighthearted exchange where Chris and Andrew discuss their future children, with a running gag about Lex Fridman's competitive desire for his kids to beat Chris's kids in jiu-jitsu. Chris then jokingly reveals his niche interest in 'octopus raising,' adding an unexpected and funny twist to the conversation about parenting and unique hobbies.
Dr. Huberman shares a personal anecdote about converting an art gallery into his living and working space, complete with a gym, an upstairs loft, a downstairs workspace, and even an octopus in a tank, fulfilling a long-held dream.
Chris explains why mold is a significant problem in Austin and other parts of Texas. He attributes it to the region's hot, humid climate combined with common US home construction practices, where organic materials like wood are exposed to the elements during building, creating prime conditions for mold growth before being sealed within the walls.
Learn about the Cortisol Awakening Response, a natural and healthy phenomenon where cortisol levels gradually rise during the night to trigger your body's waking process. This clip explains why it's a beneficial and essential part of a healthy 24-hour cycle.
Learn the best sleeping positions to enhance your brain's natural detoxification process, known as glymphatic clearance. This clip recommends sleeping on your side with your head slightly tilted and mentions innovative tools like fanny packs or rolls to help back sleepers transition to side sleeping.
Dr. Huberman delves into whether bad habits can truly be "deprogrammed," explaining that neural pathways, once laid, can be reactivated. He connects bad habits and the seven deadly sins to extreme hypothalamic functions, suggesting they are deeply rooted consummatory behaviors rather than easily erased pathways.
Chris Williamson raises an interesting point: envy is the only one of the seven deadly sins that doesn't inherently feel good or offer any enjoyment, even at low doses, distinguishing it from other sins which are often tied to pleasure-seeking hypothalamic functions.
Chris reflects on the profound disappointment and dashed expectations that come with a long and complex health journey, describing it as a 'cosmically unfair' adventure. Despite the struggles, he finds a 'silver lining' in being able to share which modalities didn't move the needle and which did, offering hope and guidance to others navigating similar challenges.
Dr. Huberman explains that breaking bad habits requires "top-down control" from the prefrontal cortex, which actively suppresses primal urges from the hypothalamus. He highlights that this self-control can be learned and, over time, may no longer be required unless the old habit is re-engaged.
Dr. Huberman explores his interest in spirituality, suggesting that virtues and resilience, particularly in overcoming addiction or immense loss, often involve a "top-down control from outside" through belief in a higher power. He notes that without this, many people resort to self-destruction.
Dr. Huberman explains how lack of sleep changes the color and appearance of your eyes due to lymph accumulation, connecting it to the brain's glymphatic clearance system.
Dr. Huberman expresses his scientific bewilderment at the spiritual phenomenon of relinquishing control, acknowledging that neuroscience currently lacks an explanation. He posits that spirituality has been central to human history and experience, suggesting that "humans evolved in the context of this" and it cannot be separated from our understanding of human evolution.
Dr. Huberman references the book "Jaws" by Paul Erlick and Sandra Khan, explaining their theory that the modern diet of soft, packet-based, and baby foods has contributed to a massive increase in orthodontic problems.
Chris Williamson reflects on the paradox that billions of people find power in "relinquishing control" to a higher power, which stands in stark contrast to the typical advice for habit formation and focus that emphasizes intention, agency, and cognitive control.
Chris recounts a terrifying experience of a migraine with aura, which he initially mistook for a stroke, including the phantom smell of 'burning toast' (a potential sign of temporal lobe seizures). This leads to a cascade of medical tests, including a CT scan with gadolinium, illustrating the confusing and often invasive diagnostic process for complex chronic illnesses like mold toxicity and Lyme disease.
Andrew Huberman explains that traditional media outlets are struggling financially because podcasts and independent creators are 'taking their paycheck.' He emphasizes that legacy media is now in a 'chase position,' competing directly with podcasts, which is why they are increasingly launching their own podcasts and resorting to sensationalized or politicized content.
Dr. Huberman revisits his past statement "it's all internal," refining it to include external spiritual influence but ultimately emphasizing the power of "internal work" for self-control. He explains that the ability to manage emotions and thoughts, like refraining from first reactions, comes from within.
Dr. Huberman advises that if you find yourself ruminating on something bothersome, it's often adaptive to distract yourself. He explains that thoughts, being layered sensory memories, can be "fed like embers in a fire," and it's important to prevent this if the rumination isn't productive.
Dr. Huberman discusses how James Nester's work on nasal breathing and mewing is a modern iteration of research by Erlick and Khan, emphasizing the importance of tongue posture and palate space, and connecting it to his own dental history.
Huberman asks Chris how he and other friends, as well as listeners, can best support someone going through a complex health battle. Chris expresses deep gratitude for Huberman's friendship, highlighting his constant support, advice, and even humorous anecdotes. Huberman then pledges his continued prayers and commitment to leverage his medical and scientific connections to help Chris in his recovery journey.
Learn why intentionally spiking your cortisol in the first hour after waking is crucial for setting a healthy cortisol curve throughout the day. This practice leads to reduced stress and anxiety in the afternoon and evening, ultimately improving sleep quality.
Discover actionable steps to effectively boost your morning cortisol, including bright light exposure (sunlight or artificial), hydration, and early exercise. Learn how these practices establish a healthy daily cortisol curve, leading to improved energy and reduced stress later in the day.
This clip explains the glymphatic system, the brain's waste clearance mechanism, discovered to be highly active during deep sleep. It details how specialized cells expand spaces around blood vessels, allowing cerebral spinal fluid to flush out metabolic waste, vital for maintaining brain health.
This clip vividly illustrates the immediate and visible consequences of poor sleep, such as facial bloating, under-eye bags (due to lymph buildup), and brain fog. It then contrasts these effects with the remarkable restorative power of a single good night's sleep on appearance and mental clarity.
Dr. Huberman advocates for "boring breaks" and silence before and after work to boost neuroplasticity and focus. He explains that post-learning reflection, often lost to smartphone use, is crucial for reinforcing new memories and information retention.
Dr. Huberman introduces neuroscientist Jenny Gro's compelling explanation of what thoughts are. He explains that thoughts begin with a "seed element" (a noun, event, etc.), and the brain then layers on more and more prior sensory memories and sensations, effectively creating abstract thought space from sensory experiences.
Building on the idea that thoughts are layered sensory memories, Dr. Huberman emphasizes the importance of limiting sensory inputs not just during work, but also *before*. He explains that prior sensory stimuli can still influence your brain, hindering focus if not managed.
Dr. Huberman contrasts historical methods of improving focus (like helmets with eyeholes for children with ADHD) with the modern challenge of smartphones. He explains that while physical space might be limited, smartphones bring an "infinite number of sensory experiences" into a single device, making cognitive space infinitely distracting.
Dr. Huberman shares his personal strategy for deep work: intentionally making himself as bored as possible and removing sensory input before starting. He describes creating a "no-phone zone" on an entire floor of his home to limit distractions and improve concentration.
Dr. Huberman shares an insight that social media algorithms heavily borrowed from casino slot machine design. He explains that slot machines were redesigned to offer "near infinite" novel combinations, exploiting the human brain's desire for novelty, making people play and feel like they're winning even when losing, a tactic now mirrored in social media.
Dr. Huberman argues that in today's distracted world, it's "very easy to be spectacularly good in pretty much any field" simply by doing what no one else is doing: deep, focused work. He explains how the brain enters "attractor states" during concentration, making it hard to leave, and encourages structured work bouts with reflection.
Chris Williamson and Dr. Huberman discuss how widespread societal distraction and fragility, while problematic, create an "exciting opportunity" and a "competitive advantage" for individuals who can cultivate focus and resilience. They frame it as a chance for personal growth and distinction.
Dr. Huberman, referencing Paul Ki, discusses how envy is often the root of many societal ills and a major impediment to personal development. He presents a "litmus test": how you truly feel when good things happen to others reveals your state of self-support or self-destruction.
Dr. Huberman discusses the intriguing paradox of how the hardest human endeavors, like maintaining sobriety from alcohol, become "far easier when they stop trying to do it for themselves" and relinquish control to a higher power, as seen in AA. He notes this phenomenon is not fully understood by neuroscience.
Dr. Huberman, a self-proclaimed man of science, shares his personal experience with a daily prayer practice and how giving over to a higher power has brought him "real deep peace." He believes that many burdens in life are difficult to navigate without such notions, even if viewed through a purely neurobiological lens.
Dr. Huberman shares his "one wish" for people: to explore the possibility of faith at some point in their lives, coupled with the practical advice to "get morning sunlight." This moment humorously combines profound spiritual guidance with his signature health recommendations.
Dr. Huberman discusses how many modern activities, including social media, mimic gambling by exploiting neural circuits of anticipation and reward. He shares a disturbing insight from a trauma therapist: some gambling addicts become addicted not to winning, but to the "shame from losing," chasing the negative self-feelings after a loss.
This moment explains the 'Cassandra complex,' where accurate predictions are met with disbelief and ridicule. It illustrates this with powerful historical examples like Cassandra from Greek mythology, Rachel Carson, Ignes Semmelweis, and the contrasting fates of Copernicus and Galileo, highlighting that being early can feel like being wrong.
Andrew Huberman advises aspiring content creators that the most important content isn't 'content about content.' He highlights that successful podcasters like Joe Rogan and Rick Rubin often achieve success in other fields first, and their life experiences then inform their unique content. He quotes Whitney Cummings: 'in order for art to imitate life, you have to live a life,' emphasizing that real-world experience is crucial for generating original and engaging ideas.
Chris uses an analogy of a narrow rock bridge with 'numbing out' and 'drama' on either side to describe the dangers of social media. He shares his experience of unfollowing accounts involved in 'boring stupid' online drama, which he felt was negatively seeding his thoughts. Andrew adds that drama on social media often gives the illusion of meaning but is ultimately 'nothingness.'
Andrew Huberman predicts that magnesium will be the next major supplement to gain widespread acceptance. He details its benefits, particularly for sleep and cognition (threonate and bisglycinate forms crossing the blood-brain barrier). Crucially, he reveals that magnesium protects against hearing loss, which is linked to dementia, explaining its role in the inner ear's endolymph. He also touches on magnesium depletion in soil due to modern farming.
Andrew Huberman clarifies the evolving scientific consensus on alcohol. He cites a Stanford analysis that re-evaluated previous studies, concluding that those which suggested moderate drinking was beneficial had flawed control groups. The current, robust finding is that 'zero is better than any' amount of alcohol, even small, due to its negative impact on cancer risk, sleep, and the microbiome.
Chris shares the origin story of his company, 'Six Month Sober Limited,' explaining how elective sobriety, even without a drinking problem, became a powerful productivity strategy for him as a young club promoter. He emphasizes the practical benefits he experienced and how he coached others, advocating for the 'just do the thing and see if you feel better' approach, similar to Andrew's advice on delaying caffeine.
Chris recounts learning from Andrew Huberman that 'locomotion with lateral eye movement on a morning walk downregulates anxiety.' He had already experienced the anxiety-reducing benefits of morning walks but appreciated understanding the neuroscientific mechanism, which 'justifies the buy-in.' Andrew adds that while the underlying mechanism is real, personal experience and the placebo effect also contribute to its effectiveness.
Huberman shares a personal medical story to illustrate how siloed medical approaches and drug categorization can lead to unexpected side effects and a 'rabbit hole' of treatments. He argues that true expertise lies in understanding the interconnected 'principles below principles,' leading to more holistic and effective solutions, as demonstrated by David Fagenbomb's work.
This segment argues that while academic degrees are necessary, they are not sufficient for true expertise. It emphasizes the importance of understanding core principles, connecting them, and being a practitioner. Chris's background as a nightclub owner and the example of Derek from More Plates More Dates are used to illustrate how real-world experience and deep, integrated knowledge can lead to profound understanding, even outside traditional academia.
Huberman provides actionable advice on incorporating low-sugar fermented foods like sauerkraut, kimchi, and kefir into daily diet to reduce inflammation and support the gut microbiome. He also delves deeper into the complex and individualized effects of fiber, acknowledging the carnivore community's claims about vegetable-induced inflammation and stressing the need to discern which fiber types are beneficial for whom.
Huberman explains the benefits of long-wavelength light (red and near-infrared) for mitochondrial health, revealing that the water surrounding mitochondria absorbs red light. He then shares the fascinating biological fact that mitochondria originated as bacteria that entered eukaryotic cells and are inherited exclusively from the mother, sparking a moment of awe.
Huberman delves into the cutting-edge and ethically complex practice of three-parent IVF, explaining how it's used to prevent the transmission of mitochondrial diseases or to address age-related egg quality issues. He details the process of combining nuclear DNA from intended parents with mitochondrial DNA from a third party, creating a child with genetic material from three individuals, and discusses the ethical considerations.
Chris introduces a humorous 'bro science' analogy: the 'V12 engine' of mitochondrial function combined with a 'Honda Civic' psychological chassis, using Kanye West as a relatable example. This lighthearted moment explores the concept of uni-heritability of mitochondria (from mom) and how it might combine with other inherited psychological traits to create distinct personalities, sparking a discussion on complex genetic interplay.
Huberman reveals a surprising truth about human genetics: it's a myth that every cell is a 50-50 mix of genes from mom and dad. He explains that entire brain areas can be genetically identical to either parent, citing research from Katherine Doolock. This debunking of a common misconception offers a deeper understanding of inheritance and its impact on attributes and even disease susceptibility.
Chris introduces the concept of 'inverse pretty privilege,' where looking outwardly fine or athletic leads to the dismissal of severe internal health struggles. He describes how many people, lacking resources or connections, accept a lower standard of living, attributing symptoms like forgetfulness, fatigue, and low mood to aging or lifestyle, when they are actually suffering from chronic underlying infections like mold and Lyme, which are complex and expensive to treat.
Chris shares his powerful recovery philosophy: 'there is basically no such thing as being overworked, only under rested.' He recounts his dramatic health decline, including a moment he forgot how to tie his shoes, and his arduous journey from a 3/10 to a 7/8 in health. This clip is a testament to resilience, the importance of fighting for a higher quality of life, and the return of 'color' to his world.
Chris recounts a surreal moment on Piers Morgan's show where Michaela Peterson attributed Jordan Peterson's severe health issues to 'demons.' This leads to a humorous (and slightly exasperated) reflection from Chris on how the 'cosmic unfairness' and overwhelming pain of chronic illness can drive people to seek supernatural explanations, like curses or karmic retribution, when conventional answers fail.
This clip debunks the common misconception that cortisol is purely a 'bad stress hormone,' explaining its essential role in deploying energy for the brain and body to react, think, and move. It clarifies that while chronic high levels are bad, cortisol is vital for daily function.
Chris introduces the 'post-content clarity' test, analogous to 'post-nut clarity,' as a way to evaluate the value of content consumption. He suggests asking yourself how you feel after consuming content (enlightened, peaceful, or stressed) and if you remember anything meaningful. Andrew elaborates, emphasizing the importance of reflection and learning over an 'endless deluge of sensory input that goes nowhere.'
Dr. Huberman shares a deeply personal story about reaching 50 and, for the first time in his life, experiencing "sustained times of real deep peace." He attributes this profound shift to stopping his resistance to the idea of God and embracing daily prayer and faith-based practices, which he previously considered incompatible with being a scientist.
Discover a unique and effective technique for falling asleep, especially when your mind is racing. This method involves specific eye movements (side-to-side, circles, and a 'faux cross-eyed' look with an exhale) to disengage your vestibular system and shift your focus away from body position, promoting sleepiness.
Dr. Huberman emphasizes that effective learning is not about repeated exposure but self-testing and active recall. He cites Peter C. Brown's book "Make It Stick," stating that "learning is repeated recall, not repeated exposure," which aligns with neuroscience.