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The Hidden Cost of Over-Exercising: How Intense Workouts Can Cause Gut Ischemia
Dr. Pradip Jamnadas explains Steven's experience with heart palpitations after an intense cycling session, revealing that over-exercising diverts blood from the gut to the muscles. This causes relative ischemia (lack of circulation) to the gut, impacting its function, a lesser-known physiological consequence of extreme physical exertion.
The Truth About Staying in Ketosis: Why Balance is Key
Dr. Jamnadas answers why, despite the benefits of ketones like increased BDNF, we shouldn't constantly stay in ketosis. He explains that human physiology is designed to utilize both glucose and fat for energy, advocating for a balanced approach rather than continuous fat burning.
A Cardiologist's Perspective: Coping with Loss and Prioritizing Quality of Life
Dr. Jamnadas reflects on the emotional toll of being a cardiologist, dealing with the heartbreak of patients losing their lives despite best efforts. He shares his perspective on the finiteness of life, emphasizing the importance of not just extending lifespan but enhancing health span and ensuring patients have the best possible quality of life until their passing.
Unmasking Modern Toxins: How Pesticides, Plastics, and Mold Disrupt Your Body
Dr. Jamnadas defines toxins as molecules that shouldn't be in the body, ranging from inadequately tested chemicals like pesticides and herbicides (which act as estrogen receptor disruptors causing inflammation) to plastics (forever chemicals like PAS and BPA), mold, and heavy metals. He explains how these disrupt metabolism and increase susceptibility to toxicity, especially when gut health is compromised.
Mold Toxicity: The Hidden Cause of Systemic Inflammation and Heart Disease
Dr. Pradip Jamnadas explains how mold toxicity, often more prevalent than imagined, causes systemic inflammatory reactions in the body, reflected in blood work, and contributes to coronary artery disease, highlighting the medical profession's slow adoption of this critical understanding.
Fasting's Hidden Power: Boosting Stem Cells and Repairing Blood Vessels
Dr. Jamnadas reveals how fasting, particularly when breaking a fast, triggers a surge of stem cells from the bone marrow. He explains how these pluripotent cells boost immunity and, crucially, how endothelial progenitor cells repair and maintain the health of blood vessels, a key benefit for cardiovascular health.
Maximize Muscle Growth: Exercise at the Peak of Your Fast
Dr. Jamnadas advises exercising at the peak of your fast, typically a couple of hours before breaking it, to leverage increased growth hormone production. He explains that intermittent fasting is the most effective way to boost growth hormone, leading to greater muscle gain and retention.
The Hidden Dangers of Excessive Fruit: Why Too Much Fructose Harms Your Heart
Dr. Pradip Jamnadas challenges the common perception of fruit as universally healthy, explaining that excessive consumption, particularly out of season, leads to high fructose intake. Fructose causes fatty liver and significantly contributes to coronary artery disease and diabetes, with a patient's health dramatically improving after reducing fruit intake.
Fasted Workouts for Women: The Type of Exercise Matters
Addressing Dr. Stacy Sims' point about women's bodies breaking down muscle during fasted workouts, Dr. Jamnadas offers a nuanced perspective. He distinguishes between exercise types, advocating for resistance training and High-Intensity Interval Training (HIIT) for women in a fasted state, while cautioning against prolonged aerobic activity to prevent glucose depletion and muscle breakdown.
Physical Indicators of Cardiovascular Health: What Your Body Tells You
Dr. Pradip Jamnadas explains how to visually assess cardiovascular health, focusing on weight and, more importantly, the presence of belly fat (visceral fat). He emphasizes that while BMI can be crude, a protruding belly is a clear indicator of a problem, even if other factors seem healthy.
The Surprising Link Between Oral Health, Sinusitis, and Heart Disease
Dr. Pradip Jamnadas reveals the unequivocal connection between oral hygiene, the oral microbiome, chronic sinusitis (especially fungal), and cardiovascular health. He explains that bad dental health and chronic infections can lead to valvular disease, premature calcification, and systemic inflammation that impacts the heart.
The Hidden Sign of Insulin Resistance: It's Not Just About Weight!
Dr. Jamnadas explains that heart damage can begin around age 30 and reveals a key visual indicator of insulin resistance: a protruding belly with fat concentrated in the stomach area, even if other parts of the body are slim. He explains why this 'phenotype' makes it hard to lose weight, linking it to insulin as a storage molecule.
Heart Palpitations: When to Worry and the Vagus Nerve Connection
Dr. Pradip Jamnadas clarifies when heart palpitations are cause for concern, distinguishing between life-threatening situations (underlying structural heart disease) and those indicating an imbalance in the nervous system. He explains how a compromised vagus nerve, often due to leaky gut or lifestyle, can lead to this imbalance and palpitations.
Are Statins Safe? Dr. Jay Reveals Side Effects & Challenges Their True Effectiveness
Dr. Jay critically examines the safety and effectiveness of statin medications. He outlines significant side effects like muscle loss, diabetes, and cognitive impairment, and questions whether their primary goal of reducing total LDL truly translates to a decrease in cardiovascular events. He suggests the focus should be on reducing damaged LDL instead of just total LDL.
Ketones: The Cleaner Fuel for Your Body and Brain
Dr. Jamnadas explains what ketones are, how they are produced from fat during fasting, and their benefits, including being a cleaner fuel source and stimulating brain-derived neurotropic factor (BDNF) for improved cognitive function.
Reversing Fatty Liver and Halting Heart Disease with Diet and Fiber
Dr. Jamnadas explains his cardiology interest in fatty liver, linking it to inflammation and coronary artery disease. He outlines how fixing fatty liver through a diet of real, unprocessed foods, increased fiber, and nutritional supplements can halt the progression of coronary calcium. He emphasizes using the coronary calcium score as a crucial marker to monitor the effectiveness of treatment and prevent further plaque buildup.
The Hidden Risk of Blood Thinners: Vitamin K2 Depletion and Heart Calcification
Dr. Jamnadas explains that blood thinners like Coumadin (warfarin) deplete both Vitamin K1 and K2, leading to increased coronary calcification. He emphasizes the critical need for Vitamin K2 supplementation, as modern diets often lack sufficient amounts from fermented foods, making it challenging to obtain enough K2 naturally.
Beyond Diet: How Sleep and Stress Impact Your Gut Health
Dr. Jamnadas expands on gut health, highlighting crucial lifestyle factors beyond diet. He stresses the absolute importance of adequate sleep (7 hours a night), explaining how lack of sleep negatively alters the gut microbiome, affects overall physiology, repair processes, and can even cause insulin resistance after just one bad night. He also touches on the impact of frequent time zone changes and the need for omega-3s.
Beyond Blockages: The Real Cause of a Heart Attack Revealed
Dr. Jamnadas demystifies what truly causes a heart attack, explaining that it's not just plaque buildup (which causes angina) but rather the *cracking* of a minor plaque. He details how this rupture leads to a blood clot forming, which is the final event that shuts down the artery. Crucially, he states that inflammation is the underlying cause of plaque rupture. He also reveals that only 20% of patients with blockages experience chest pain.
Your Normal A1C Doesn't Mean You're Safe: The Hidden Insulin Problem
Dr. Jamnadas reveals that a 'normal' A1C and blood sugar don't mean you're healthy if you have chronically high insulin. He explains how this background hyperinsulinemia destroys metabolism, leading to fatty liver and the accumulation of highly detrimental visceral fat, a direct result of frequent consumption of starchy carbohydrates and glucose.
Why Fasting Beats Calorie Restriction for Fat Loss
Dr. Jamnadas explains the fundamental difference in body physiology between fasting and simple calorie restriction. He highlights how calorie deficits slow metabolism and lead to muscle loss, whereas fasting lowers insulin, enabling the body to 'pull fat out of the bank' and specifically target visceral fat after 12 hours.
Your Fasting Blueprint: Protocols for Visceral Fat, Weight Loss & Diabetes
Dr. Jamnadas outlines various fasting protocols tailored to different goals, starting with 12/12 for visceral fat reduction, progressing to 18/6, and then more intensive options like a weekly 48-hour fast or a 3-day water fast with OMAD for severe overweight or diabetes reversal.
The Autophagy Advantage: Why Cycling Out of Ketosis is Crucial
Dr. Jamnadas explains why continuously staying in a ketogenic state is not ideal and advocates for cycling in and out, including regular 36-hour fasts for healthy individuals. He then delves into autophagy, describing how cells clean out redundant parts and repair mitochondria, leading to improved cellular function, increased energy, and reduced reactive oxygen species.
The Surprising Truth About Exercise and Heart Health: Less Aerobics, More Resistance
Dr. Jamnadas challenges common beliefs about exercise for heart health, explaining that excessive aerobic activity can lead to inflammation and coronary artery disease. He advocates for a balanced approach: 15-20 minutes of aerobic exercise for endurance, followed by resistance training (bodyweight or HIT) with specific rest periods. This method helps the body manage reactive oxygen species, leading to a cleaner physiology and better heart health.
The Shocking Link: How a Bad Gut Microbiome Causes Heart Disease in Healthy Individuals
Dr. Jamnadas shares a compelling case study of a seemingly healthy 60-year-old man with no traditional risk factors, yet a high coronary calcium score. He reveals that the root cause was a lifelong dysfunctional gut microbiome, leading to chronic inflammation and ultimately, coronary artery disease, highlighting how often overlooked gut health can significantly impact cardiovascular well-being.
The Gut-Liver Connection: How Your Microbiome Impacts Fatty Liver and Heart Health
Dr. Jamnadas explains the critical role of the gut microbiome, detailing the symbiotic relationship with bacteria and viruses. He describes how a dysfunctional microbiome can lead to a 'leaky gut,' allowing bacterial products into the bloodstream, which then travel to the liver, causing inflammation and fatty liver disease—an epidemic affecting 25% of the population. He links this directly to processed foods, sugar, and toxins.
Stop Taking Calcium Supplements: The Dangers and the D3/K2 Solution
Dr. Jamnadas issues a strong warning against calcium supplements, stating they can increase cardiovascular event risk. He explains that the real problem is often a deficiency in Vitamin D3 and K2. He advises patients to stop calcium supplements and instead take D3 for absorption and K2 to prevent calcium buildup in arteries, highlighting how a lack of these vitamins can lead to conditions like osteopenia despite high calcium intake.
Transform Your Gut: Essential Diet Tips for a Healthy Microbiome
Dr. Jamnadas provides actionable advice for achieving a healthy gut, emphasizing two key strategies: consuming lots of fiber and incorporating fermented foods. He explains how fiber feeds good bacteria, warns against sugar's impact on bad bacteria, and recommends supplements like inulin with FOS. He also champions fermented foods like kefir for their diverse bacteria and postbiotics, stressing the importance of eating a wide variety of unprocessed vegetables and spices to foster a diverse gut microbiome.
The 'End Up on My Surgical Table' Diet: Foods to Avoid for Heart Health
Dr. Pradip Jamnadas uses reverse psychology to list the worst foods for heart health, including nutrient-deficient processed foods, refined wheat products, fast foods, and drinks with artificial colorings, sweeteners, and even orange juice, emphasizing the lack of fiber and profound insulin spikes.
Transforming White Rice: A Cardiologist's Guide to Reducing Arsenic and Creating Resistant Starch
Dr. Pradip Jamnadas provides a surprising, multi-step method for preparing white rice to reduce arsenic and convert it into resistant starch, which lessens its insulin impact and feeds gut bacteria, highlighting the problem of food sourcing and the need for a cardiologist to teach cooking.
Ditch Vegetable Seed Oils: The Key to a Healthy Omega Ratio and Heart Health
Dr. Pradip Jamnadas strongly advises against vegetable seed oils due to their exceedingly high omega-6 content, which creates an unhealthy omega-6 to omega-3 ratio. He recommends replacing them with extra virgin olive oil for salads and butter, ghee, or coconut oil for high-temperature cooking.
The Real Reason Coffee is Good: Beyond Caffeine to Fiber and Polyphenols
Dr. Pradip Jamnadas challenges the popular belief that coffee's benefits come from caffeine, explaining that its true value lies in its soluble fiber and polyphenols. These components feed good gut bacteria, leading to postbiotics that reduce leaky gut and inflammation, and protect the vagus nerve.
Hack Your Vagus Nerve: Simple Techniques for Better Health
Dr. Jay explains actionable ways to stimulate your vagus nerve for improved health, relaxation, and stress management. He covers nutritional supplements, specific breathing exercises, eye movements, cold water application, humming, singing, laughing, and the Valsalva maneuver.
The Truth About LDL: Why 'Small Dense LDL' is the Real Problem, Not Total Cholesterol
Dr. Jay breaks down the critical difference between total LDL cholesterol and 'small dense damaged LDL' particles, explaining how only the latter causes inflammation and atherosclerosis. He reveals the five primary culprits behind the formation of these harmful particles, challenging the common understanding of cholesterol's role in heart disease.
The Only Two Tests You Need to Screen for Heart Disease & Inflammation
Dr. Jay outlines two essential tests for anyone over 30 concerned about heart health and inflammation: a coronary calcium score and a comprehensive inflammatory panel like Cleveland Heart Labs. He explains what these tests reveal about your risk and importantly, how inflammation can manifest not just physically, but also as mental fog and depression.
72-Day Water Fast: Reversing Diabetes, Hypertension & Losing 60lbs (with disclaimer)
Dr. Jamnadas shares a remarkable case study of a woman who completed a 72-day water fast under supervision, reversing diabetes, normalizing blood pressure, and losing 55-60 lbs, while addressing common concerns about women and fasting. He details the allowed liquids (water, black tea/coffee, electrolytes, MCT oil for cravings) and issues a crucial disclaimer about medical supervision.
Hidden Heart Killers: Excessive Cardio, Mold, Bad Sleep, and Arsenic in Rice?
Dr. Jamnadas highlights several unexpected factors detrimental to cardiovascular health. He controversially suggests that excessive aerobic activity can lead to more coronary artery disease than sprints, and points out the prevalence of mold toxicity in homes. He also mentions that even one night of bad sleep makes you insulin resistant, and warns about calcium supplements, excessive fruit, and surprisingly high arsenic levels in white rice.
Dr. Jay's Toughest Day & The Power of Living in the Present Moment
Dr. Jay shares the deeply personal story of his father's passing, describing it as the most difficult day of his life. He explains how this profound experience taught him about his own limitations and motivated his dedication to educating others. This leads to a powerful reflection on the importance of living in the present moment, a skill he cultivated to overcome regret and anxiety, and how it can lead to greater happiness and effectiveness for everyone.