🎬 Episode Moments

The Chemistry of Food & Taste | Dr. Harold McGee

huberman
June 29, 2025
27 Moments

🎯 All Moments (27)

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Wine Tasting: Is Expensive Wine Really Better?

McGee and Huberman discuss the subjective nature of wine tasting and the influence of expectations on perception. They discuss how knowledge and curiosity can enhance appreciation, but blind taste tests often fail to distinguish expensive wines from cheaper ones.

Wine controversy
1:29
Duration: 0:07

Growing Your Own Tea: Tips for Cultivating Tea Plants

McGee shares insights on growing tea plants, explaining that they are easy to grow and don't need a sunny spot. He notes that the newest leaves are used for tea making and that shade-grown tea is often preferred for flavor. He mentions that he has had his tea plants for almost 20 years and uses tea making as a way to keep them in check.

Tea Plants knowledge
1:02:46
Duration: 2:39

The Authentic Way to Smoke Cheese: Warding off Bugs with Smoke

McGee explains that authentic smoked flavors come from keeping cheeses in a room with smoldering material. This was originally done to ward off bugs from the nutritious food.

food science knowledge
1:41:21
Duration: 0:55

Why Copper Bowls Are Used in Jam and Jelly Making

Harold McGee explains that copper inhibits the breakdown of sucrose into glucose and fructose during jam and jelly making, which is why French cooks have traditionally used copper bowls for preserves. This clip provides an interesting historical and chemical reason for a specific cooking practice.

Food Chemistry knowledge
4:15
Duration: 0:39

The French Way: Why Soup Should Be First, Salad Last

Huberman and McGee discuss food course order, sharing personal anecdotes and cultural insights. Huberman recounts a girlfriend from the south of France who insisted on soup first and salad last for optimal digestion and taste. McGee supports this order, explaining how soup can help fill the stomach and salad can refresh the palate before dessert.

Food Culture story
37:24
Duration: 5:17

The Maillard Reactions: How Browning Meat Creates Sugars and Flavor

McGee explains that browning meat involves the Maillard reactions, which occur between fragments of proteins, carbohydrates, and fats. These reactions generate various products, including sugars, contributing to the complex flavor profile of cooked meat. This clip clarifies the chemical basis for the color and taste changes in cooked meat.

Food Chemistry knowledge
18:25
Duration: 0:39

The Downside of Over-Processing: Why Natural Flavors Matter

McGee discusses how processing food with vanilla extract, sugars, and other additives overwhelms the palate, masking the natural flavors of the original ingredients. He emphasizes the value of savoring natural ingredients like strawberries and blueberries, appreciating their individual components, and avoiding the immediate hit of flavor from processed foods.

Processed Foods knowledge
50:40
Duration: 2:07

The Art of Tea: Tannis, Leaf Treatment, and Flavor

McGee explains the factors affecting the tanic flavor in tea, including the tea leaf's treatment and the presence of large molecules. He shares his experience making tea from his backyard tea bushes, experimenting with different processing techniques to create various types of tea. He also describes how drying the leaves and using hot water impacts the final flavor.

Tea knowledge
1:00:30
Duration: 1:35

The Science Behind Crystals in Aged Cheese: Tyrosine and Authenticity

McGee explains that aged cheese crystals are tyrosine or amino acid derivatives, created when proteins break down and dehydrate, becoming insoluble. While these crystals are a sign of authenticity, the question remains if they enhance nutrient availability.

food chemistry knowledge
1:39:52
Duration: 1:07

From Astronomy to Food Science: A Serendipitous Career Journey

McGee shares his personal journey from astronomy and literature to food science, sparked by a simple question about why beans cause gas. This led to a book deal and a career exploring the science of food.

career knowledge
1:53:32
Duration: 1:17

The Ancient History of Alcohol and Chocolate

McGee and Huberman discuss the history of alcohol consumption, tracing it back to pre-homo sapiens primates enjoying fermented fruit. They also touch on the discovery of chocolate and its fermentation process.

Alcohol knowledge
1:18
Duration: 0:11

Why Kids Are Picky Eaters: Heightened Senses and Managing Food Aversions

McGee explains that kids' heightened senses make them more sensitive to nuances in food, leading to a temporary conservatism in their diets. He also shares his approach to dealing with picky eaters, offering a variety of foods without forcing consumption.

nutrition knowledge
1:58:44
Duration: 1:52

The Surprising Benefit of Using a Copper Bowl for Egg Whites

Harold McGee explains how using a copper bowl to whip egg whites makes a noticeable difference in color, texture, and consistency compared to other bowls. This is due to the chemical interactions between the copper and the egg whites, a fact that was known centuries ago. This clip highlights a surprising and actionable tip for improving cooking results.

Food Chemistry knowledge
3:04
Duration: 0:39

Reset Your Taste Buds: How to Adjust Your Sweet and Bitter Thresholds

McGee explains how taste preferences and thresholds for bitterness and sweetness can change over time. He references studies showing that people can adjust their sodium intake preferences and that becoming accustomed to a certain level of stimulation sets a new normal. Huberman shares his experience of developing a taste for cacao beans, which were initially too bitter.

Taste Preferences knowledge
43:59
Duration: 2:55

Is Tea at the End of a Meal Bad?

Huberman asks if there is a belief that tea shouldn't be had at the end of a meal since it hardens food in the stomach. McGee believes that is nonsense.

Tea controversy
1:05:45
Duration: 0:17

Polyphenols & Food Combinations: What You Need to Know

McGee explains how polyphenols interact with proteins and debunks the idea that certain food combinations should be avoided for optimal digestion, emphasizing individual tolerance.

Digestion knowledge
39:00
Duration: 0:00

Supertasters: The Genetics of Taste Explained

McGee discusses the genetic basis of taste perception, highlighting the existence of "supertasters" who have a higher density of taste buds and are more sensitive to bitterness.

Taste Perception knowledge
4:15
Duration: 0:08

The Chemistry of Cheese: Why Aged Cheese Tastes Better

McGee explains that aged cheeses are more flavorful due to the breakdown of proteins and fats by microbes over time and the formation of flavor molecules.

Cheese knowledge
1:36
Duration: 0:03

How to Reduce Gas from Eating Beans: Soaking and Gut Adaptation

McGee explains how soaking beans helps reduce gas by leaching out carbohydrates that our bodies can't digest. He also notes that our gut microbiome can adapt to better tolerate beans over time.

digestion knowledge
1:55:12
Duration: 1:54

The Savory Sensation of Umami and Its Discovery

McGee and Huberman discuss umami, its savory qualities, and the historical disbelief in the West regarding its existence as a basic taste. McGee recounts enjoying pan drippings as a child, highlighting the deliciousness of braised meat. The clip also touches on the discovery of the glutamate receptor and the unique fullness and length associated with umami.

Umami knowledge
13:34
Duration: 2:53

Coffee Chemistry: Grind Size, Water Temperature, and Flavor

McGee shares insights into coffee brewing, highlighting the importance of grind size and water temperature. He explains that extracting coffee involves removing soluble materials, with larger molecules causing bitterness and astringency. He suggests an experiment to taste the different extraction stages and notes that water temperature affects the flavor.

Coffee Brewing knowledge
56:20
Duration: 1:18

How Heat Transforms Food Molecules to Enhance Flavor

McGee explains that cooking breaks down macromolecules (proteins, carbs, fats) into smaller molecules that we can taste and smell. Heat rearranges and breaks down these molecules, creating new flavors and aromas. This clip provides a fundamental understanding of how cooking enhances the sensory experience of food.

Food Chemistry knowledge
9:12
Duration: 1:35

The Chemical Reactions That Make Cooked Steak Taste Better

McGee explains that cooking meat breaks down proteins and fats into smaller, reactive molecules. These molecules react with each other and oxygen, creating volatile molecules that stimulate our taste and smell receptors. This clip clarifies the chemical processes behind the enhanced flavor of cooked meat compared to raw meat.

Food Chemistry knowledge
11:28
Duration: 1:08

The Origins of Fermentation: From Overripe Fruits to Global Cuisine

McGee shares the origin of fermentation, noting that it was likely discovered through simple observation of overripe fruits. He highlights the global prevalence of fermentation, even in Arctic regions, and discusses the transformation of traditional foods through shared knowledge and new applications.

fermentation knowledge
1:45:15
Duration: 4:08

The Chemistry of Taste: How Chewing Releases Hidden Flavors

McGee explains how enzymes in our mouths interact with food molecules (conjugates) to release aromatic compounds, enhancing the taste experience. He emphasizes the benefits of eating slowly to fully appreciate these evolving flavors, and Huberman discusses how we have more control over our taste experiences than our visual perception.

Taste knowledge
33:04
Duration: 2:59

How to Cut Onions Without Crying: Chemistry-Based Tips

McGee explains the chemistry behind why onions make us cry and provides practical tips to minimize the effect, such as wearing goggles or rinsing the onion with water while cutting.

Cooking advice
4:01
Duration: 0:14

Why Some People Taste Soap in Cilantro: The Science of Divergent Taste

McGee discusses the divergent taste experiences of cilantro, explaining that some people perceive a soapy flavor due to the presence of molecules also found in soaps. This difference is often linked to cultural exposure rather than inherent biological factors.

taste perception knowledge
2:00:55
Duration: 1:21