The Science of Gratitude & How to Build a Gratitude Practice | Huberman Lab Essentials

Episode Moments

The Science of Gratitude & How to Build a Gratitude Practice | Huberman Lab Essentials

huberman
October 23, 2025
14 Moments

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The Science of Genuine Thanks: Why Intention Matters More Than the Gift

Andrew Huberman discusses a scientific study that reveals the critical role of intention in feeling gratitude. He explains that while the amount of a benefit matters, the genuine, wholehearted intention of the benefactor has a far greater impact on activating gratitude circuits, emphasizing that 'genuine thanks are what count.'

Gratitude knowledge
24:13
Duration: 1:32

How Gratitude Changes Your Brain Circuits and Heart-Brain Interaction

This clip explains how repeated gratitude practice can alter neural circuits and the reciprocal communication between the brain and heart, impacting overall well-being. It references a study on 'neural network functional connectivity and brain heart coupling'.

Gratitude knowledge
26:43
Duration: 0:59

How the Medial Prefrontal Cortex Defines Your Experience

This moment explains the crucial role of the medial prefrontal cortex (mPFC) in planning, evaluating experiences, and especially in setting the context and defining the meaning of our experiences, which is vital for understanding gratitude.

Neuroscience knowledge
8:55
Duration: 0:39

The Physiological Benefits of Consistent Story-Based Gratitude

Discover the profound physiological impact of a consistent, story-based gratitude practice. Huberman explains how returning to a potent story not only activates brain circuits for pro-social behaviors but also creates a perceptible shift in heartbeat and breathing, leading to a reproducible state of gratitude that benefits both mind and body.

Gratitude Practice knowledge
22:54
Duration: 1:19

The Scientific Edge: Why Story-Based Gratitude Outperforms Simple Lists

This moment contrasts the scientifically grounded, story-based gratitude practice with common, less effective methods like simple lists. It highlights how the former profoundly shifts physiology, immune system, and neural circuitry, leading to reduced anxiety and increased motivation.

Gratitude practice knowledge
33:43
Duration: 0:56

Why 'Fake It Till You Make It' Doesn't Work for Gratitude

This clip debunks the common self-help myth that one can simply 'fake it till you make it' with gratitude. It explains that our neural circuitry, while powerful and plastic, is not 'stupid' and knows when we are lying to ourselves about an experience.

Gratitude controversy
12:24
Duration: 0:35

Why Listing Gratitude Fails: The Brain Needs Story, Not Lists

Andrew Huberman explains why the common practice of simply listing things you're grateful for is ineffective, revealing that our neural circuits for gratitude (serotonin, oxytocin) are instead activated by powerfully associating with the idea of receiving help, best conveyed through someone else's story.

Gratitude Practice knowledge
19:09
Duration: 1:15

Build Your Own Story-Based Gratitude Practice in Minutes

Learn the practical steps to create an effective, story-based gratitude practice. Huberman explains how observing or imagining stories of help and human spirit activates gratitude circuits, and how to condense these powerful narratives into a short, repeatable daily practice for profound emotional benefits.

Gratitude Practice advice
20:24
Duration: 2:30

The 'Twofer' Benefit: Gratitude Reduces Anxiety & Boosts Motivation

Discover how a regular gratitude practice can scientifically shift your brain's functional connectivity, making anxiety and fear circuits less active while enhancing feelings of well-being and motivation. This is presented as a powerful incentive for practice.

Gratitude knowledge
27:42
Duration: 1:20

Gratitude's Impact on Immunity: Reduces Inflammation and Amygdala Activity

Learn about a study demonstrating how gratitude practice can rapidly reduce amygdala activity (linked to fear) and decrease inflammatory markers like TNF alpha and IL6, benefiting overall health and immunity. The effects were observed almost immediately.

Gratitude knowledge
29:02
Duration: 2:32

The Science of Choice: How Your Brain Transforms Discomfort into Benefit

This moment illustrates how conscious choice and motivation, mediated by the medial prefrontal cortex, can transform a negative experience like an ice bath into one with positive neurochemical and immune benefits (dopamine, anti-inflammatory markers), contrasting it with being forced.

Choice knowledge
9:53
Duration: 0:58

The Surprising Science: Receiving Gratitude is More Potent Than Giving

This moment reveals the surprising, research-backed finding that receiving gratitude is significantly more potent for activating positive neural shifts than giving gratitude. It explains the specific study involving co-workers and letters of thanks that demonstrated this robust effect on prefrontal networks.

Gratitude Practice knowledge
14:32
Duration: 1:03

Your Brain's 'Knob': How Medial Prefrontal Cortex Frames Experience

A concise and powerful metaphor explaining how the medial prefrontal cortex acts as a 'knob' or 'switch' that frames our experiences, determining whether they lead to positive or negative health effects based on our perception and choice.

Mindset knowledge
11:30
Duration: 0:17

Building an Effective Gratitude Practice: The Story-Based Method

This clip outlines the key elements of a scientifically effective gratitude practice. It emphasizes grounding the practice in a genuine narrative (either receiving or observing thanks) and using simple bullet points as emotional cues for a focused 1-5 minute reflection.

Gratitude practice advice
31:34
Duration: 2:09