Tricyclic antidepressants are a class of medications used to treat depression by increasing norepinephrine levels in the brain. They were among the first drugs discovered to relieve depression symptoms.
One of the most important early findings in the search for a biological basis of depression was this finding that there are drugs that relieve some of the symptoms of depression. Those drugs generally fall into three major categories. But the first set of ones that were discovered were the so-called tricyclic anti-dopressants
""Andrew Huberman mentions tricyclic antidepressants as a class of drugs used to relieve some symptoms of depression by increasing norepinephrine levels. A listener might be interested in this product if they are exploring different treatment options for depression."