NMN (Nicotinamide Mononucleotide)
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📝 Description
NMN (Nicotinamide Mononucleotide) is a precursor to NAD+ (Nicotinamide Adenine Dinucleotide), a coenzyme found in all living cells essential for various biological processes, including metabolism, DNA repair, and cell signaling. Dr. Sinclair mentions that taking NMN can double NAD levels in the blood, which he believes is crucial for activating sirtuin longevity genes and maintaining a youthful cellular function. He has been taking it for years and observes a personal benefit in his cognitive function and overall feeling of youthfulness.
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Along the lines of supplementation, what about NMN? How does one incorporate that into a a supplementation protocol should they choose to do that? All right. Well, disclaimer is I don't recommend anything, but I talk about what I do. So, a bit of scientific background. these sertuan genes that we discovered first in yeast cells when I was at MIT and then uh in animals as I moved to Harvard in the 2000s um and one of one of my first postocs actually literally my first postoc hen published a great paper and found that turning on the s two and six gene remember the seven number six gene is very potent it extended the lifespan dramatically of mice that he engineered both males and females which is great so what you want to do is naturally boost the activity of these certuins They are genes, but they also make proteins. That's what genes typically make or encode. And then those proteins take care of the body in many different ways. NAD levels are really important for keeping those certain defenses at a youthful level. I take a precursor to NAD called NMN and the body uses that to make the NAD molecule in one step.
"🎬 Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair
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🤖 Why This Product Was Mentioned
"Dr. Andrew Huberman asks Dr. David Sinclair about NMN and how to incorporate it into a supplementation protocol. Dr. Sinclair, a leading researcher in aging, explicitly states that he takes NMN as a supplement and explains its role as a precursor to NAD+. He discusses its importance for activating sirtuin genes, which he believes are key to longevity and combating aging, and shares his personal experience and observations from studying dozens of people who take NMN."
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